PRENATAL SCREENING OF HEMOGLOBINOPATHIES SS AND CC: 25 YEARS OF EXPERIENCE IN THE PROVINCE OF VILLA CLARA, CUBA
DOI:
https://doi.org/10.52428/20756208.v10i24.549Keywords:
Hemoglobinopathies, Sickle cell disease, Hemoglobin S, Hemoglobin CAbstract
Hemoglobinopathies is the medical term that describes a group of disorders affecting the red blood cells. The homozygous state for hemoglobin S is the most common and severe form, although compound heterozygotes for hemoglobin S and C are included also. An observational, descriptive and transversal study was performed, which displays the results of 25 years of the prenatal screening program of hemoglobinopathies SS and SC in the province of Villa Clara, Cuba, during the period 1988-2012.
4 660 pregnant women were diagnosed with these hemoglobinopathies and 4 193 husbands were studied. We identified 144 high-risk partners and 126 of them agreed to prenatal diagnostic procedures. 24 affected fetuses were diagnosed, of which in 17 cases the couple decided to elective termination of pregnancy. The adjusted prevalence rate of these hemoglobinopathies in Villa Clara during the studied period was 0,95 per 10 000 live births.
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Copyright (c) 2015 Noel Taboada Lugo , Melba Gómez Rojo , Ana E. Algora Hernández , Gretsy Arcas Ermeso , María D. Noa Machado y Manuela Herrera Martínez
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