CONSANGUINITY PRESENCE IN EUROPEAN MONARCHIES AND ITS RELATIONSHIP WITH DIFFERENT GENETIC DISEASES.
DOI:
https://doi.org/10.52428/20756208.v9i20.582Keywords:
Consanguinity, Consanguineous marriages, Inbreeding, Medical GeneticsAbstract
The negative effects of consanguineous marriages are well documented and are usually in genetic diseases, in which a percentage of cases died. A literature review was conducted in order to document the presence of consanguinity in different European monarchies and its relationship with different genetic diseases.
Consanguinity in the Spanish Royal family is documented, which caused the extinction of that family. Another example was the Victoria Queen of England, who transmitted hemophilia to several dynasties, such as British, Prussian, Spanish and Russian; this disease at the end of XIX century hemophilia was known as "The Royal Disease".
The type of hemophilia transmitted in diferent European dynasties was never identified; but recent anthropological and molecular genetic studies allowed determine it was type B of hemophilia.
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References
BITTLES AH. A background summary of consanguineous marriage. [en línea] 2006 [fecha de acceso 29 de marm de 2013]. URL disponible en: www.consang.net.
CHARSLESWORTH D, WILLIS JH. The genetics of inbreeding depression. Nature Reviews Genetics, 2009; 10:783-796. DOI: https://doi.org/10.1038/nrg2664
CEBALLOS FC, ÁLVAREZ G. La genética de los matrimonios consanguíneos. Dendra Médica. Rev Humanid.
SAGGAR AK, BITTLES AH. Consanguinity and child health. Paediatr Child Health. 2008,18:244-249. DOI: https://doi.org/10.1016/j.paed.2008.02.008
BITTLES AH. Consanguinity and its relevance to clinical genetics. Clin Genet. 2001 ; 60(2):89-98. DOI: https://doi.org/10.1034/j.1399-0004.2001.600201.x
BARRETO l, SANS M. Consanguinidad y Endogamia. Atlas of Genetics and Cytogenetics in Oncology and Haematology. [en línea] 2008 [fecha de acceso 29 de marzo de 20131. URL disponible en: http://atlasgeneticsoncology.org/Educ/ConsangSplD30039SS.html.
DOMENECH J. Incesto Real. Los matrimonios entre familia de los faraones. [en línea] 2008 [fecha de acceso 29 de marzo de 2013]. URL disponible en: http://suite101 .net/article/los-matrimonios-entre-familia-de-los-faraones 01796
FERRANDO M. La sexualidad en el Antiguo Egipto. [en línea] 2008 [fecha de acceso 29 de marzo de 2()13]. URL disponible en: http://www.juridicas.unam.mx/publica/librev/rev/hisder/cont/10/cnt/cnt26.pdf
GLADSTONE WE. Juventus mundi; the gods and men of the heroic age. London: Macmillan and co. 1869.
SAGRADA BIBLIA. Traducido de la Vulgata Latina por José Miguel Petisco. 9 a ed. Madrid: Editorial Apostolado de la Prensa; 1964.
GARCÍA MG. El amor en los tiempos del cólera. Barcelona: Bruguera. 1985.
CANNON J, GRIFFITHS, R. The Oxford Illustrated History of the British Monarchy. Oxford: Oxford University Press; 2000.
HISTORY OF THE MONARCHY. [en línea] The oficial website of the British Monarchy. 2012 [fecha de acceso
de marzo de 2013]. URL disponible en:http://www.royal.gov.uk/HistoryoftheMonarchy/HistoryoftheMonarchy.aspx
ÁLVAREZ G, CEBALLOS FC, Quinteiro C. El «hechizo» genético de Carlos ll. Invest y Ciencia.2010:10-11.
COLECCIÓN ON LINE MUSEO NACIONAL DEL PRADO. [en línea] [fecha de acceso 29 de marzo de 2013]. URL disponible en: http://www.museodelprado.es/coleccion/galeria-on-line/galeria-on-line/obra/carlos-ii-l/
Combined pituitary hormone deficiency. On line Mendelian Inheritance in Men. [en línea] [fecha de acceso 29 de marzo de 2013]. URL disponible en: http://omim.org/entry/262600?search=262600&highlight=262600
Renal tubular acidosis. On line Mendelian Inheritance in Men. [en línea] [fecha de acceso 29 de marzo de 2013]. URL disponible en: http://omim.org/entry/602722?search=602722&highlight=602722
La endogamia mató a los Austrias. [en línea] 2009 [fecha de acceso 29 de marzo de 2013]. URL disponible en: http://elpais.com/diario/2009/04/15/sociedad/1239746409_850215. html
FRASER A. The Lives of the Kings & Queens of England. Berkeley. University of California Press; 1998.
INGRAM GE. The History of Hemophilia. J. Clin. Pathol. 1976; 29(6): 469-479. DOI: https://doi.org/10.1136/jcp.29.6.469
Hemophilia A. On line Mendelian Inheritance in Men. [en linea] [fecha de acceso 29 de marzo de 2013]. URL disponible en: http://omim.org/entry/306700?search=306700&highlight=306700
Hemophilia B. On line Mendelian Inheritance in Men. [en linea] [fecha de acceso 29 de marzo de 2013]. URL dis ponible en: http://omim.org/entry/306900?search=306900&highlight=306900
STEVENS R. The history of haemophilia in the royal families of Europe. Br J Haematol. 1999: 105(1):25-32. DOI: https://doi.org/10.1111/j.1365-2141.1999.01327.x
RUBIO A, LUCIA JE Hemofilia: Historia de la Realeza. Madrid: Real Fundaciön "Victoria Eugenia"; 2000.
La Monarquia en la Historia de Espafia. [en linea] Casa de su Majestad el Rey. 2012. [fecha de acceso 29 de marzo de 2013]. URL disponible en:
http://www.casareal.es/ES/MonarquiaHistoria/Paginas/subhome_monarquia.aspx
ROGAEV El, GRIGORENKO AP, MOLIAKA YK, FASKHUTDINOVA G, GOLTSOV A, LAI-ITI A, et al: Genomic identification in the historical case of the Nicholas Il royal family. Proc Natl Acad Sci USA 2009; 106(13):5258-5263. DOI: https://doi.org/10.1073/pnas.0811190106
ROGAEV El, GRIGORENKO AP, FASKHUTDINOVA G, KITTLER EL, MOLIAKA YK: Genotype analysis identifies the cause of the "Royal Disease". Science 2009; 326(5954):817. DOI: https://doi.org/10.1126/science.1180660
LANNOY N, HERMANS C. The 'royal disease'--haemophilia A or B? A haematological mystery is finally solved. Haemophilia.2010; DOI: https://doi.org/10.1111/j.1365-2516.2010.02327.x
GIANGRANDE P. Historical review. Six Characters in search of an author: The history of nomenclature of coagulation factors. British J Haematol.2003, 121 , 703—712. DOI: https://doi.org/10.1046/j.1365-2141.2003.04333.x
AH, BLACK ML. Consanguinity, human evolution, and complex diseases. PNAS 2010 107 (suppl 1) 1779-1786 DOI: https://doi.org/10.1073/pnas.0906079106
BITTLES AH. Endogamy, consanguinity and community genetics. J Genet. 2002 Dec; 81 DOI: https://doi.org/10.1007/BF02715905
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