Update on genetic and epigenetic mechanisms in the origin of congenital defects sensitive to maternal folic acid deficiency
DOI:
https://doi.org/10.52428/20756208.v13i36.476Keywords:
Birth Defects, Gene, Epigenetic, Folic acidAbstract
Congenital defects constitute the fi rst cause of childhood death in developed countries and the second rate in many developing countries. There are many genes involved in embryonic development which act during the morphologic period. Study of genetic mechanisms related with the origin of many congenital defects had been a vertiginous increasing, as well as different epigenetic mechanisms related with maternal deficiency of folic acid. An updated review was performed with the aim to provide updated information about genetic and epigenetic mechanisms involved in the origin of some birth defects related with maternal deficiency of folic acid and other micronutrients. Published medical literature in Spanish and English was retrieved through searchers of PubMed, Medline, Scielo, Lilacs and the Cochrane Library in September 2018, using appropriate keywords. The fact of epigenetics alterations, in contrast with genetics mechanism as mutations, are potentially reversible, has important implications for implementation of strategies to prevent different birth defects sensitized to the maternal deficiency of folic acid. Keywords: Birth defects. Gene. Epigenetic. Folic acid.
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