Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico

Autores/as

  • Melanie Maldonado Servicios de Ciencia & Tecnologia (SC&T)

DOI:

https://doi.org/10.52428/20758944.v17i50.21

Palabras clave:

COVID-19, Dióxido de cloro, Pruebas clínicas randomizadas, Razonamiento crítico

Resumen

Desde hace algunos años, productos como el dióxido de cloro, clorito de sodio y suplemento mineral milagroso (o MMS por sus siglas en inglés), a pesar de no haber sido certificados como medicamentos, están siendo utilizados de manera alternativa por muchas personas para el tratamiento de diferentes enfermedades. Este uso se ha visto incrementado durante la actual crisis por la pandemia por COVID-19. En este documento, se proporciona una lista no exhaustiva de publicaciones científicas y advertencias oficiales respecto al uso potencialmente peligroso de estos productos en el área de la salud humana. Toda la información citada es bien conocida por profesionales de ramas afines a la bioquímica y farmacéutica, pero no siempre es accesible al público en general. Además, se proporcionan elementos de razonamiento crítico para ayudar a la población en general a procesar la evidencia científica disponible y así construir una opinión propia e independiente

Citas

ABC News. (2016). Husband Says Fringe Church's 'Miracle Cure' Killed His Wife. ABC News. Retrieved 22 November, 2020, from https://abcnews.go.com/US/husband-fringe-churchs-miracle-cure-killed-wife/story?id=43081647

Abdel-Rahman, M. S., Couri, D., y Bull, R. J. (1982). Metabolism and Pharmacokinetics of Alternate Drinking Water Disinfectants. Environmental Health Perspectives, 46(19-23). https://doi.org/10.1289/ehp.824619

Agency for Toxic Substances and Disease Registry (1998). Toxic Substances Portal - Chlorine Dioxide and Chlorite. Dióxido de Cloro y Clorito, TOXFAQs. Retrieved 22 November, 2020, from https://www.atsdr.cdc.gov/es/toxfaqs/es_tfacts160.html

Arkes, H. R., y Ayton, P. (1999). The Sunk Cost and Concorde Effects: are humans less rational than lower animals?, Psychological Bulletin, 125(5), 591-600. https://doi.org/10.1037/0033-2909.125.5.591

Arnold, J., y Rushton, W. (2018, January). The mineral miracle disaster: accidental poisoning after use of 28% sodium chlorite solution resulting in methemoglobinemia and mild hemolytic anemia. Clinical Toxicology, 56(10), 941-942. https://doi.org/10.1080/15563650.2018.1506610

Arnstein, P., Broglio, K., Wuhrman, E., y Kean, M. B. (2011). Use of placebos in pain management. Pain Management Nursing, 12 (4): 225-9. https://doi.org/10.1016/j.pmn.2010.10.033

Atkins, P. W. (1986). Fisicoquímica. Addison Wesley.

Bathina, G., Yadla, M., Burri, S., Enganti, R., Prasad Ch, R., y Deshpande, P. (2013). An Unusual Case of Reversible Acute Kidney Injury Due to Chlorine Dioxide Poisoning. Renal Failure, 35(8), 1176-8. https://doi.org/10.3109/0886022x.2013.819711

BBC (2010). Firms fined £350,000 for chlorine dioxide death. BBC News. Retrieved 22 November, 2020, from https://www.bbc.com/news/uk-england-leicestershire-11409491

Bercz, J. P., Jones, L., Garner, L., Murray, D., Ludwig, D. A., y Boston, J. (1982). Subchronic toxicity of chlorine dioxide and related compounds in drinking water in the nonhuman primate. Environmental Health Perspectives, 46, 47-55. https://doi.org/10.1289/ehp.824647

Brenon-Audat, F., Busquet, C., y Mesnil, C. (1993). Thermodynamique chimique. Hachette: Paris.

Brocker, K. A., Nehls, K., Sohn, C., y Eichbaum, M. (2011). Massive Vaginal Epitheliolysis After Treatment of LSIL and Human Papilloma Virus with Chlorine Dioxide. Geburtshilfe und Frauenheilkunde, 71(6), 521-524. https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s- 0030-1271145

Brockway, L. O. (1933). The Three-Electron Bond in Chlorine Dioxide. Proceedings of the National Academy of Sciences, 19, (3), 303-307. https://doi.org/10.1073/pnas.19.3.303

Burke, D., Zakhary, B., y Pinelis, E. (2014). Acute Hemolysis Following an Overdose of Miracle Mineral Solution in a Patient with Normal Glucose-6-Phosphate Dehydrogenase Levels. CHEST Journal, 146(4), 273A. https://doi.org/10.1378/chest.1988668

Bundesinstitut für Arzneimittel und Medizinprodukte (2015). Bundesinstitut für Arzneimittel und Medizinprodukte stuft zwei ’Miracle Mineral Supplement’-Produkte als zulassungspflichtig und bedenklich ein. Retrieved 22 November, 2020, from https://www.bfarm.de/SharedDocs/Pressemitteilungen/DE/2015/pm3-2015.html

Bundesinstitut für Risikobewertung (2012). BfR rät von der Einnahme des Produkts 'Miracle Mineral Supplement (MMS)' ab. Retrieved 22 November, 2020, from https://mobil.bfr.bund.de/cm/343/bfr-raet-von-der-einnahme-des-produkts-miracle-mineral-supplement-mms-ab.pdf

Bundesamt für Sicherheit im Gesundheitswesen (2020). Warnung vor Miracle Mineral Supplement MMS in der EU und Österreich. Retrieved 22 November, 2020, from https://www.basg.gv.at/warnung-vor-miracle-mineral-supplement-mms

Butler, T. (2017). The Jarisch–Herxheimer Reaction After Antibiotic Treatment of Spirochetal Infections: A Review of Recent Cases and Our Understanding of Pathogenesis. The American Journal of Tropical Medicine and Hygiene, 96(1), 46-52. https://doi.org/10.4269/ajtmh.16-0434

Carl Roth (2017). Planillas de datos de seguridad para el Clorito de sodio (Traducido del alemán). Carl Roth, Sicherheitsdatenblatt. Retrieved 22 November, 2020, from https://www.carlroth.com/medias/SDB-4352-DE-DE.pdf?context=bWFzdGVyfHNlY3VyaXR5RGF0YXNoZWV0c3wyNzM5MDZ8YXBwbGljYXRpb24vcGRmfHNlY3VyaXR5RGF0YXNoZWV0cy9oZWUvaDZjLzg5NDc4MTYyMDIyNzAucGRmfDkwY2UwMzk4Zjk0NGI2NTMyY2Q3NzJhN2M2MWU5OTk5ZGZlN2YzYWU4MThhMjI5NWJiMjQwZ

Carrione, E. I., y Genesis Foundation (2020). Determination of the Effectiveness of Oral Chlorine Dioxide in the Treatment of COVID 19. ClinicalTrials.gov Identifier: NCT04343742. https://clinicaltrials.gov/ct2/show/study/NCT04343742?term=chlorine+dioxide&draw=2&rank=1

Chaplin, S. (2006). The placebo response: an important part of treatment. Prescriber, 17 (5): 16–22. https://doi.org/10.1002/psb.344

Children's hospital of Philadelphia (2019). Dangerous Trend: Chlorine Dioxide and Autism. Center for Injury Research and Prevention. Retrieved 22 November, 2020, from https://injury.research.chop.edu/blog/posts/dangerous-trendchlorine-dioxide-and-autism

U.S. Department of Health and Human Services (2004). Toxicological profile for

chlorine dioxide and chlorit. Retrieved 22 November, 2020, from https://www.atsdr.cdc.gov/toxprofiles/tp160.pdf

Departamento de Salud y Servicios para Personas Mayores de New Jersey (2005). Hoja de informaciones sobre sustancias peligrosas. Retrieved 22 November, 2020, from https://nj.gov/health/eoh/rtkweb/documents/fs/0368sp.pdf

Dhakal, A., y Sbar, E. (2020, November 20). Jarisch-Herxheimer Reaction: a review. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID: 32491752 NBK557820

Deutsche Verbraucherzentrale (2020). Miracle Mineral Supplement (MMS): Erhebliche Gesundheitsgefahr. Retrieved 22 November, 2020, from https://www.verbraucherzentrale.de/wissen/lebensmittel/nahrungsergaenzungsmittel/miracle-mineral-supplement-mms-erhebliche-gesundheitsgefahr-11044

DiNardo, J. (2008). Natural Experiments and Quasi-Natural Experiments. In: Palgrave Macmillan (eds) The New Palgrave Dictionary of Economics. Palgrave Macmillan, London. https://doi.org/10.1057/978-1-349-95121-5_2006-1

Dobson, S., y WHO (2002). Chlorine Dioxide (Gas). International Chemical Assessment Document 37. Retrieved 22 November, 2020, from https://www.who.int/ipcs/publications/cicad/en/cicad37.pdf

Edgar, A., y Salek, S. (2002). Pharmaceutical Ethic. Wiley, 1st Ed

Enck, P., Klosterhalfen, S., Weimer, K., Horing, B., y Zipfel, S. (2011). The placebo response in clinical trials: more questions than answers. Philosophical Transactions of the Royal Society B, 366(1572), 1889-1895. https://doi.org/10.1098/rstb.2010.0384

Environmental Paper Network (2018). The state of the global paper industry. Executive Summary. Retrieved 22 November, 2020, from https://environmentalpaper.org/wp-content/uploads/2018/04/StateOfTheGlobalPaperIndustry2018_FullReport-Final-1.pdf

ERCO worldwide (2020). Safety Data Sheet. ERCO worldwide. Retrieved 22 November, 2020, from http://www.ercoworldwide.com/wp-content/uploads/SDSC-Chlorine-Dioxide-Solution.pdf

Everitt, B.S. (2002), The Cambridge Dictionary of Statistics, CUP. ISBN 0-521-81099-X

Fair Warning (2019). There’s Been an Uptick in the Use of the Crackpot Cure, Miracle Mineral Solution. Fair Warning. News of public health, consumer and environmental issues. Retrieved 22 November, 2020, from https://www.fairwarning.org/2019/09/theres-been-an-uptick-in-the-use-of-the-crackpot-cure-miracle-mineral-solution/

Flesch, R., Plenge, J., y Rühl, R. (2006). Core-level excitation and fragmentation of chlorine dioxide. International Journal of Mass Spectrometry, 249-250, 68-76. https://doi.org/10.1016/j.ijms.2005.12.046

Gebhardtova, A., Vavrinec, P., Vavrincova-Yaghi, D., Seelen, M., Dobisova, A., Flassikova, Z., Cikova, A., Henning, R., y Yaghi, A. (2014). A Case of Severe Chlorite Poisoning Successfully Treated with Early Administration of Methylene Blue, Renal Replacement Therapy, and Red Blood Cell Transfusion. Medicine, 93(9), p. e60. https://doi.org/10.1097/MD.0000000000000060

Gefährdung durch (2010). Gemeinsames Giftinformations­zentrum. Gefährdung durch "Miracle Mineral Supplement" MMS. Retrieved November 22, 2020, from https://www.ggiz-erfurt.de/aktuelles-detail/miracle-mineral-supplement.html

Gilovich, T. D., Griffin, D., y Kahneman, D. (2002). Heuristics and Biases: The Psychology of Intuitive Judgment. New York, NY: Cambridge University Press.

Hagiwara, Y., y Inoue, N. (2015). First Case of Methemoglobinemia Caused by a ClO2-based Household Product. Pediatrics International, 57(6), 1182-3. https://doi.org/10.1111/ped.12708

Hariton, E., y Locascio, J. J. (2018). Randomised controlled trials - the gold standard for effectiveness research. BJOG: An International Journal of Obstetrics & Gynaecology, 125 (13), 1716-1716. https://doi.org/10.1111/1471-0528.15199

Harrington, R. M., Romano, R. R., Gates, D., y Ridgway, P. (1995). Subchronic Toxicity of Sodium Chlorite in the Rat. Journal of the American College of Toxicology, 14(1), 21-33. https://doi.org/10.3109/10915819509008678

Harris, A. D., McGregor, J. C., Perencevich, E. N., Furuno, J. P., Zhu, J., Peterson, D. E., y Finkelstein, J. (2006). The use and interpretation of quasi-experimental studies in medical informatics. Journal of the American Medical Informatics Association, 13(1), 16-23. https://doi.org/10.1197/jamia.M1749

Hulshof, P.B. J.E., Veenstra, J., y van Zwieten, R. (2018, September 19). Severe Hemolytic Anemia Due to Transient Acquired G6PD Deficiency After Ingestion of Sodium Chlorite. Clinical Toxicology, 57(1), 65-66. https://doi.org/10.1080/15563650.2018.1491984

In Bailar, J. C. (1953). Chlorine (IV) Oxide. Inorganic syntheses: Volume 4., 152-158.

Jim, H., y Lloyd, C. (1998). Ein gesundes Leben mit MMS (Vol. ISBN: 9789088791758). Jim Humble Verlag.

Kalcker, A. L. (2017). Gesundheit verboten (1st ed., Vol. ISBN: 978-9088791567). Humble, Jim Verlag.

Levine, I. N. (1981). Fisicoquímica. McGraw-Hill: Bogotá.

Lim, J. L., y Lim, P. K. (2009). Acute Sodium Chlorite Poisoning Associated with Renal Failure. Renal failure, 15, 645-8. https://doi.org/10.3109/08860229309069417

Loh, J. M., y Shafi, H. (2014). Kikuchi-Fujimoto disease presenting after consumption of 'Miracle Mineral Solution' (sodium chlorite). BMJ case reports 2014. https://doi.org/10.1136/bcr-2014-205832

Ma, J. W., Huang, B. S., Hsu, C. W., Peng, C. W., Cheng, M. L., Kao, J. Y., Way, T. D., Yin, H. C., y Wang, S. S. (2017). Efficacy and Safety Evaluation of a Chlorine Dioxide Solution. International Journal of Environmental Research and Public Health, 14, 329. https://doi.org/10.3390/ijerph14030329

MedWatch der Rechercher verschieben (2019). Tribunal Federal Alemán de Justicia confirma sentencia de prisión para vendedores de MMS. Bundesgerichtshof bestätigt Haftstrafe für MMS Verkäufer. MedWatch. Retrieved 22 November, 2020, from https://medwatch.de/2019/07/23/erloese-von-350-000-euro-bundesgerichtshof-bestaetigt-haftstrafe-fuer-mms-verkaeufer/

Mieli, A. (1945). Volta y el desarrollo de la electricidad. Espasa Calpe: Buenos Aires.

Ministerio de salud – Bolivia (2020). Comunicado documentado sobre dióxido de cloro. Retrieved 22 November, 2020, from https://www.minsalud.gob.bo/images/Descarga/covid19/COM-Dioxi-DOC.pdf?fbclid=IwAR3XXueEECYJ8kfKaZEdjqJj7gxvR6VhFHYWmKN-I7RrI36CuiT213OdL18

Moore, G. S., y Calabrese, E. J. (1980a). The effects of chlorine dioxide and sodium chlorite on erythrocytes of A/J and C57L/J mice. Journal of Environmental Pathology and Toxicology, 4(2-3), 513-524. https://pubmed.ncbi.nlm.nih.gov/7462915/

Moore, G. S., y Calabrese, E. J. (1980b). G6PD-deficiency: A Potential High-Risk Group to Copper and Chlorite Ingestion. Journal of Environmental Pathology and Toxicology, 4(2-3), 271-279.

Moore, G. S., Calabrese, E. J., Di Nardi, S. R., y Tuthill, R. W. (1978). Potential Health Effects of Chlorine Dioxide as a Disinfectant in Potable Water Supplies. Medical Hypotheses, 4(5), 481-496. https://doi.org/10.1016/0306-9877(78)90017-8

National Institute of Standards and Technology (2018). Chlorine dioxide. NIST Chemistry WebBook. Retrieved 22 November, 2020, from https://webbook.nist.gov/cgi/cbook.cgi?ID=10049-04-4

Nguyen, V., Hoffman, R. S., y Nelson, L. S. (2014). Chlorine dioxide from a dietary supplement causing hemolytic anemia. Clinical Toxicology, 52, 323. https://doi.org/10.3109/15563650.2014.906213

Nicolas, F.D. A.A., Mesonero, R., Molero, V., Nieto, M., Herreros, C., Ruiz, A., y Murillo, E.D.E. (2016). Irritant contact dermatitis from 'miracle mineral solution'. Journal of the American Academy of Dermatology, 74(5), 2757. https://doi.org/10.1016/j.jaad.2016.02.362

Nisbert, R. E., y Wilson, T. D. (1977). The halo effect: Evidence for unconscious alteration of judgments. Journal of Personality and Social Psychology, 35(4), 250-256. https://doi.org/10.1037/0022-3514.35.4.250

Nishikori, R., Nomura, Y., Sawajiri, M., Masuki, K., Hirata, I., y Okazaki, M. (2008). Influence of chlorine dioxide on cell death and cell cycle of human gingival fibroblasts, Journal of Dentistry, 36(12), 993-998. https://doi.org/10.1016/j.jdent.2008.08.006

Ogata, N., y Shibata, T. (2008). Protective effect of low-concentration chlorine dioxide gas against influenza A virus infection. Journal of General Virology, 88(1), 60-67. https://doi.org/10.1099/vir.0.83393-0

Oswald, A. (2020). Das neue MMS Handbuch - Gesundheit in eigener Verantwortung (9th ed., Vol. ISBN 978-3-9815255-0-2). Peter Daniel Verlag.

Pauling, L. (1988). General chemistry. Mineola, NY: Dover Publications.

Patat. (2011). Intoxication aiguë après ingestion de Solution Minérale Miracle (MMS) à base de chlorite de sodium. Journal de Pédiatrie et de Puériculture, 24(2), 109. https://doi.org/10.1016/j.jpp.2010.12.003

Petrucci, R. H. (2017). Química general: Principios y aplicaciones modernas. Madrid: Pearson Educación

Rivera, K. (2013). Healing the Symptoms Known as Autism (2nd ed., Vol. ISBN: 0989289044, 9780989289047). Amazon Digital Services LLC - KDP Print US.

Romanovsky, A., Djogovic, D., y Chin, D. (2013). A case of sodium chlorite toxicity managed with concurrent renal replacement therapy and red cell exchange. Journal of Medical Toxicology, 9(1), 67-70. https://doi.org/10.1007/s13181-012-0256-9

Sarrazin, J., y Verdaquer, M. (1989). L'oxydoréduction. Ellipse: Paris.

Sisler, H. H., Vanderwerf, C. A., y Davidson, A. W. (1959). General Chemistry. A systematic approach. Macmillan: Nueva York.

Stigler, S. M., (1997). Regression toward the mean, historically considered. Statistical Methods in Medical Research, 6 (2): 103-114. PMID 9261910. https://doi.org/10.1191/096228097676361431

Swadle, T. W. (1997). Inorganic chemistry: an industrial and environmental perspective (ISBN 0-12-678550-3 ed.). Academic Press. pp. 198-199.

Taylor, J. B. (2010). Toxicological Profile for Chlorine Dioxide (Vol. ISBN 1437930794, 9781437930795). DIANE Publishing.

Umweltbundesamt Deutschland (2011). Límite para la utilización de dióxido de cloro como desinfectante para el agua potable en Alemania (Traducido del alemán). Umweltbundesamt. Retrieved 22 November, 2020, from https://www.umweltbundesamt.de/sites/default/files/medien/3521/dokumente/trinkwasserdesinfektion_pruefung_der_wirksamkeit_von_desinfektionsmitteln.pdf

U.S. Environmental Protection Agency (2000). Toxical Review: Chlorine Dioxide and Chlorite. U.S. Environmental Protection Agency Washington, DC. Retrieved 22 November, 2020, from https://cfpub.epa.gov/ncea/iris/iris_documents/documents/toxreviews/0648tr.pdf

U.S. Food and Drug Administration (2019a). Fraudulent Coronavirus Disease 2019 (COVID-19) Products. Retrieved 22 November, 2020, from https://www.fda.gov/consumers/health-fraud-scams/fraudulent-coronavirus-disease-2019-covid-19-products

U.S. Food and Drug Administration (2019b). Danger: Don’t Drink Miracle Mineral Solution or Similar Products. Retrieved 22 November, 2020, from https://www.fda.gov/consumers/consumer-updates/danger-dont-drink-miracle-mineral-solution-or-similar-products#:~:text=The%20FDA%20warns%20you%20not,products%20can%20make%20you%20sick.&text=If%20you're%20drinking%20%E2%80%9CMiracle,sodium%20chlorite%20products%2C%20stop%20now

U.S. Food and Drug Administration (2020). FDA Warns Seller Marketing Dangerous Chlorine Dioxide Products that Claim to Treat or Prevent COVID-19. Retrieved 22 November, 2020, from https://www.fda.gov/news-events/press-announcements/coronavirus-covid-19-update-fda-warns-seller-marketing-dangerous-chlorine-dioxide-products-claim

Upton, G., y Cook, I. (2006) Oxford Dictionary of Statistics, OUP. ISBN 978-0-19-954145-4

Vogt, H., Balej, J., Bennett, J. E., Wintzer, P., Sheikh, S. A., Gallone, P., Vasudevan, S., y Pelin, K. (2010). Chlorine Oxides and Chlorine Oxygen Acids. onlinelibrary.wiley.com. https://onlinelibrary.wiley.com/doi/10.1002/14356007.a06_483.pub2

Williams, S. R., Dawling, S., y Seger, D. L. (2009). Severe hemolysis in pediatric case after ingestion of Miracle Mineral Solution. Clinical Toxicology, 47(7), 737. https://doi.org/10.1080/15563650903076924

World Health Organization (2020a). Guidelines on the implementation of the WHO certification scheme on the quality of pharmaceutical products moving in international commerce. WHO, Access to Medicines, Vaccines and Pharmaceuticals. Retrieved 22 November, 2020, from https://www.who.int/medicines/areas/quality_safety/regulation_legislation/certification/guidelines/en/

World Health Organization (2020b). Preguntas y respuestas sobre la enfermedad por coronavirus (COVID-19). Organización Mundial de la Salud. Retrieved 22 November, 2020, from https://www.who.int/es/emergencies/diseases/novel-coronavirus-2019/advice-for-public/q-a-coronaviruses

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2021-06-01

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Maldonado, M. (2021). Sobre el uso del dióxido de cloro en ámbitos de la salud humana y la importancia del razonamiento crítico. Journal Boliviano De Ciencias, 17(50), 6–31. https://doi.org/10.52428/20758944.v17i50.21

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